Neural Control and Coordination
The neural system and the endocrine system jointly coordinate and integrate all activities of the organs so that they function in a synchronised fashion. The neural system provides an organised network of point-to-point connections for quick coordination, while the endocrine system provides chemical integration through hormones.
Human neural system
Divided into two parts:- Central neural system (CNS): brain and spinal cord; site of information processing and control.
- Peripheral neural system (PNS): all nerves associated with the CNS.
Neuron
Three major parts: cell body (with Nissl's granules), dendrites (carry impulses towards cell body) and axon (carry impulses away). Axon terminals end in synaptic knobs with synaptic vesicles containing neurotransmitters.- Types by number of axons/dendrites: multipolar (cerebral cortex), bipolar (retina), unipolar (embryonic stage).
- Axons: myelinated (Schwann cells form a myelin sheath; gaps are nodes of Ranvier; in spinal and cranial nerves) and unmyelinated (no sheath; in autonomic and somatic systems).
Nerve impulse
- Resting potential: at rest the membrane is more permeable to K+ and nearly impermeable to Na+. Na-K pump moves 3 Na+ out for 2 K+ in. Outer surface positive, inner negative (polarised).
- Action potential: a stimulus makes the membrane freely permeable to Na+; rapid Na+ influx reverses polarity (depolarisation). This action potential is the nerve impulse. The impulse spreads along the axon; rising K+ permeability and K+ efflux restore the resting potential.
Synapse
Junction between a pre-synaptic and a post-synaptic neuron. Two types:- Electrical synapse: membranes very close; current flows directly; faster than chemical; rare in our system.
- Chemical synapse: separated by a synaptic cleft; uses neurotransmitters. Impulse causes vesicles to fuse and release neurotransmitters, which bind receptors on the post-synaptic membrane, opening ion channels and generating a new potential that may be excitatory or inhibitory.
Brain (Central Neural System)
Covered by cranial meninges: dura mater (outer), arachnoid (middle), pia mater (inner). Three major parts:- Forebrain: cerebrum, thalamus, hypothalamus. Cerebrum has two hemispheres joined by the corpus callosum; cortex = grey matter (cell bodies), inner = white matter (myelinated tracts). Thalamus = sensory and motor coordinating centre. Hypothalamus controls temperature, hunger and thirst and secretes hypothalamic hormones. The limbic system regulates emotions, sexual behaviour and motivation.
- Midbrain: between thalamus/hypothalamus and pons; has the cerebral aqueduct and corpora quadrigemina (four dorsal lobes).
- Hindbrain: pons (fibre tracts), cerebellum (convoluted surface, coordination/balance) and medulla (controls respiration, cardiovascular reflexes and gastric secretions).
- Brain stem = midbrain + pons + medulla oblongata; connects brain and spinal cord.